Diabetes Drug - reduce risk of dementia?

Diabetes drug could reduce risk of dementia by 20 per cent

The most widely used drug for type 2 diabetes could reduce the risk of people with the condition developing dementia by as much as 20 per cent according to research presented at Alzheimer’s Association International Conference in Boston on Monday 15 July 2013.
Scientists at Kaiser Permanante studied the use of a number of diabetes treatments on 14,891 people over the age of 55 with type 2 diabetes. The study, which took place over five years, showed that participants who received the insulin sensitiser metformin were 20 per cent less likely to develop dementia than the baseline group, who received another treatment. Other therapies including insulin and TZD saw no reduction in risk of dementia.
Clinical trials are underway to establish the use of metformin as a therapy for both dementia and mild cognitive impairment, which is thought could be a precursor to Alzheimer’s disease.
Alzheimer’s Society comment:
‘The more we learn about dementia and how it relates to other conditions like diabetes, the more we’re able to explore whether existing drugs can double as dementia treatments. This study suggests that the drug metaformin may be one of the most promising candidates to do just that.
One in three people over the age of 65 will develop dementia. Given the huge cost and high profile failures of developing new treatments from scratch, looking at ways to use drugs like this to treat dementia is incredibly important.’
Jess Smith
Research Officer     Alzheimer’s Society
Research reference: Rachel Whitmer et al, ‘Anti-Hyperglycemic Therapy and Risk of Dementia: A New User Cohort Study’. Presented at Alzheimer’s Association International Conference, July 15 2013. 
  • One in three people over 65 will develop dementia
  • Alzheimer’s Society research shows that 800,000 people in the UK have a form of dementia, more than half have Alzheimer’s disease. In less than ten years a million people will be living with dementia. This will soar to 1.7 million people by 2051
  • Alzheimer’s Society champions the rights of people living with dementia and the millions of people who care for them
  • Alzheimer’s Society works in England, Wales and Northern Ireland
  • Alzheimer’s Society has a plan to deal with dementia. Help us support people to live well today and fight for a world without dementia tomorrow. We rely on voluntary donations to continue our vital work. You can donate now by calling 0845 306 0898 or visiting alzheimers.org.uk
  • Alzheimer’s Society provides a National Dementia Helpline, the number is 0300 222 11 22 or visit alzheimers.org.uk
© Alzheimers Society - 15th July 2013 

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